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Clozapine induced severe weight loss in resistant schizophrenia managed with risperidone add-on therapy

Authors:

M. Chandradasa ,

University of Kelaniya, Ragama, LK
About M.

Department of Psychiatry, Faculty of Medicine

Colombo North Teaching Hospital, Ragama

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C. S. Kuruppuarachchi,

General Sir John Kotelawala Defence University, Colombo, LK
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L. C. Rathnayake,

National Institute of Mental Health, Angoda, LK
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K. A. L. A. Kuruppuarachchi

University of Kelaniya, Ragama, LK
About K. A. L. A.

Department of Psychiatry, Faculty of Medicine

 

Colombo North Teaching Hospital, Ragama

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Abstract

Clozapine is prescribed for resistant schizophrenia. It is usually associated with weight gain. There have been only a few reports of weight loss associated with clozapine treatment and we report two patients from Sri Lanka. The first patient lost 27% of bodyweight on clozapine while the second lost 17%. Both were clinically stable on clozapine, with marked reduction of psychotic symptoms. Adding risperidone helped to regain the lost weight in the described patients.
How to Cite: Chandradasa, M., Kuruppuarachchi, C.S., Rathnayake, L.C. and Kuruppuarachchi, K.A.L.A., 2020. Clozapine induced severe weight loss in resistant schizophrenia managed with risperidone add-on therapy. Sri Lanka Journal of Psychiatry, 11(2), pp.38–39. DOI: http://doi.org/10.4038/sljpsyc.v11i2.8259
Published on 02 Dec 2020.
Peer Reviewed

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