Abstract Marchiafava Bignami Disease is a rare neurodegenerative disorder affecting corpus callosum. It is usually associated with chronic use of alcohol leading to nutritional deficiencies. However, its aetiology is not completely understood. Clinical features of this condition are paralysis, confusion, cognitive deficits, aggression, apraxia, ataxia, coma and seizures. Degeneration of the corpus callosum can be identified in MRI brain. Prognosis of MBD is variable. There are reported cases of complete recovery, partial recovery and death. Administration of high doses of thiamine, vitamin B complexes and steroids has shown benefits in some cases. I this case report, a 48 year old chronic alcohol user treated with high doses of Thiamine, completely recovered from MBD.